The lab has a strong publication record, with several articles published
yearly in journals with high impact factors. Members of the lab work
not only on molecular research projects, but also on clinical research
as well. Each lab member also typically works on a review article of
either a clinical or molecular nature. Dr. Gupta works to ensure that
students are assigned to projects that accord with their future career
Original Research (Molecular)
Rafijah G et al. The effects of adjuvant fibrin sealant
on the surgical repair of segmental nerve defects in an animal
model. The Journal of hand surgery. 38, (5):847-55 (2013).
Chao T et
al. Matrix metalloproteinase 3 deletion preserves denervated
motor endplates after traumatic nerve injury. Annals of neurology 73, 210–23 (2013).
Lin MY et al. Biophysical Stimulation induces
demyelination via an integrin-dependent mechanism. Annals of
Neurology. 72, (1):112-23
Gupta R et al. Chronic nerve compression alters Schwann
cell myelin architecture in a murine model. Muscle & Nerve. 45(2):231-41
Chao T, Pham K, Steward O, Gupta R. Chronic nerve compression injury
induces a phenotypic switch of neurons within the dorsal root ganglia.
J. Comp. Neurol. 506(2):180-93 (2008).
Dinh P, Bhatia N, Rasouli A, Suryadevara S, Cahill K, Gupta R. Transplantation
of preconditioned Schwann cells following hemisection spinal cord injury.
Spine. 32(9):943-49 (2007).
Gray M, Palispis W, Popovich PG, van Rooijen N, Gupta R. Macrophage
depletion alters the blood-nerve barrier without affecting Schwann
cell function after neural injury. J. Neurosci. Res. 85(4):766-77 (2007).
Rasouli A, Bhatia N, Suryadevara S, Cahill K, Gupta R. Transplantation
of preconditioned schwann cells in peripheral nerve grafts after contusion
in the adult spinal cord. Improvement of recovery in a rat model. J.
Bone Joint Surg. Am. 88(11):2400-10 (2006).
Berger BL, Gupta R. Demyelination secondary to chronic nerve compression
injury alters Schmidt-Lanterman incisures. J. Anat. 209(1):111-18 (2006).
Gupta R, Rummler LS, Palispis W, Truong L, Chao T, Rowshan K, Mozaffar
T, Steward O. Local down-regulation of myelin-associated glycoprotein
permits axonal sprouting with chronic nerve compression injury. Exp.
Neurol. 200(2):418-29 (2006).
Gupta R, Channual JC. Spatiotemporal pattern of macrophage recruitment
after chronic nerve compression injury. J. Neurotrauma. 23(2):216-26
Gupta R, Truong L, Bear D, Chafik D, Modafferi E, Hung CT. Shear stress
alters the expression of myelin-associated glycoprotein (MAG) and myelin
basic protein (MBP) in Schwann cells. J. Orthop. Res. 23(5):1232-39
Gupta R, Gray M, Chao T, Bear D, Modafferi E, Mozaffar T. Schwann
cells upregulate vascular endothelial growth factor secondary to chronic
nerve compression injury. Muscle Nerve. 31(4):452-60 (2005).
Azanchi R, Bernal G, Gupta R, Keirstead HS. Combined demyelination
plus Schwann cell transplantation therapy increases spread of cells
and axonal regeneration following contusion injury. J. Neurotrauma.
Gupta R, Rowshan K, Chao T, Mozaffar T, Steward O. Chronic nerve compression
induces local demyelination and remyelination in a rat model of carpal
tunnel syndrome. Exp. Neurol. 187(2):500-8 (2004).
Gupta R, Lin YM, Bui P, Chao T, Preston C, Mozaffar T. Macrophage
recruitment follows the pattern of inducible nitric oxide synthase
expression in a model for carpal tunnel syndrome. J. Neurotrauma. 20(7):671-80
Chafik D, Bear D, Bui P, Patel A, Jones NF, Kim BT, Hung CT, Gupta
R. Optimization of Schwann cell adhesion in response to shear stress
in an in vitro model for peripheral nerve tissue engineering. Tissue
Eng. 9(2):233-41 (2003).
Gupta R, Steward O. Chronic nerve compression induces concurrent apoptosis
and proliferation of Schwann cells. J. Comp. Neurol. 461(2):174-86
Gupta, R; Allen, FA; Tan, V; Bozentka, DJ; Bora, FW; sterman, AL.
The effect of laminar fluid flow on fibroblasts derived from Dupytren's
tissue and normal palmar fascia. J. Hand Surgery. 23A:945-50 (1998).
Lorich, DG; Brighton, CT; Gupta, R; Corsetti, JR; Levine, SE; Gelb,
ID; Seldes, R, Pollack, SR. Biochemical pathway mediating the response
of bone cells to capacitive coupling. Clinical Orthop. & Rel. Res.
Bernot, M, Gupta, R, Dobrasz, B, Chance, B, Heppenstall, RB, Sapega,
AA. The effect of antecedent ischemia on the tolerance of skeletal
muscle to increased interstitial pressure. J. Orthop. Trauma 10(8):555-59
Original Research (Clinical)
Shapiro TA, McGarry MH, Gupta R, Lee YS, Lee TQ. Biomechanical effects
of glenoid retroversion in total shoulder arthroplasty. J. Shoulder
Elbow Surg. 16(3 Suppl):S90-95 (2007).
Karamanoukian R, Gupta R, Evans GR. A novel technique for the prophylactic
plating of the osteocutaneous radial forearm flap donor site. Ann.
Plast. Surg. 56(2):200-04 (2006).
Gupta R, Bingenheimer E, Fornalski S, McGarry MH, Osterman AL, Lee
TQ. The effect of ulnar shortening on lunate and triquetrum motion--a
cadaveric study. Clin. Biomech. 20(8):839-45 (2005).
Gupta R, Lee TQ. Positional-dependent changes in glenohumeral joint
contact pressure and force: possible biomechanical etiology of posterior
glenoid wear. J. Shoulder Elbow Surg. 14(1 Suppl S):105S-110S (2005).
Kobayashi MR, Brenner KA, Gupta R, Evans GR. Functional biceps brachii
reconstruction using the free tensor fasciae latae. Plast. Reconstr.
Surg. 114(5):1208-14 (2004).
Gupta R, Jones NF. A novel method of skeletal fixation in an above-elbow
replantation: the dowel pin technique. Plast. Reconstr. Surg. 111(7):2349-52
Gupta R, Allaire RB, Fornalski S, Osterman AL, Lee TQ. Kinematic analysis
of the distal radioulnar joint after a simulated progressive ulnar-sided
wrist injury. J. Hand Surg. 27(5):854-62 (2002).
Gupta, R; Villablanca, PJ; Jones, NF Evaluation of an acute compression
injury in an animal model by magnetic resonance neurography.
J. Hand Surg. 26A: 1093-99 (2001).
Gupta R, Rummler L, Steward O. Understanding the biology of compressive
neuropathies. Clin. Orthop. Relat. Res. (436):251-60 (2005).
Rummler L, Gupta R. Peripheral nerve repair: a Review. Curr. Opin.
Orthop. 15:215-19 (2004).
Rummler, LS; Dinh, PT; Gupta, R. The anatomy and biochemistry of myelin
and myelination. Oper. Tech. Orthop. 14(3):146-152 (2004)
Kang J, Gupta R. Mechanisms of fatty degeneration in massive rotator
cuff tears. Journal of shoulder and elbow surgery / American
Shoulder and Elbow Surgeons ... [et al.] 21, 175–80 (2012).
JR, Zamorano DP, Gupta R. Limb Salvage with major nerve injury:
current management and future directions. J Am Acad Orthop
Surg 19, S28-S34 (2011).
Tafti MA, Cramer SC, Gupta R. Orthopaedic management of the upper
extremity of stroke patients. J Am Acad Orthop Surg. 16(8):462-70 (2008).
Strandberg EJ, Mozaffar T, Gupta R. The role of neurodiagnostic studies
in nerve injuries and other orthopedic disorders. J Hand Surg. 32(8):1280-90
Gupta R, Lee TQ. Contributions of the different rabbit models to our
understanding of rotator cuff pathology. J. Shoulder Elbow Surg. 16(5
Ecklund KJ, Lee TQ, Tibone J, Gupta R. Rotator cuff tear arthropathy.
J. Am. Acad. Orthop. Surg. 15(6):340-9 (2007).
Fornalski S, Gupta R, Lee TQ. Anatomy and biomechanics of the elbow joint.
Tech. Hand Up. Extrem. Surg. 7(4):168-78 (2006).
Dinh PT, Gupta R. Subtotal medial epicondylectomy as a surgical option
for treatment of cubital tunnel syndrome. Tech. Hand Up. Extrem. Surg.
Chafik D, Lee TQ, Gupta R. Total elbow arthroplasty: current indications,
factors affecting outcomes, and follow-up results. Am. J. Orthop. 33(10):496-503
Rowshan K, Jones N, Gupta R. Current surgical techniques of peripheral
nerve repair. Oper. Tech. Orthop. 214(3):163-70 (2004).
Gupta R, Mozaffar T. Peripheral Nerve Physiology, Anatomy, and Pathology.
In: Buckwalter JA, Einhorn TA, O'Keefe RJ (eds). Orthopedic Basic Science:
Biology and Biomechanics of the Musculoskeletal System. 3rd Ed.
American Academy of Orthopedic Surgeons, Rosemont, Illinois (in press).
Gupta R, Mozaffar T. Form and Function of the Spinal Cord and Peripheral
Nerves. In: Buckwalter JA, Einhorn TA, O'Keefe RJ (eds). Orthopedic
Basic Science: Biology and Biomechanics of the Musculoskeletal System.
3rd Ed. American Academy of Orthopedic Surgeons, Rosemont, Illinois